Psychiatric and neurological disorders are devastating to individuals, their families, and society. These disorders account for nearly one-fifth of all disability leading to ill health or early death worldwide and cost the US economy over $1 trillion per year, more than any single category of disease. Created with the transformative grant of $45 million from the Roy J. Carver Charitable Trust, the Iowa Neuroscience Institute (INI) seeks revolutionary discoveries in fundamental neuroscience to translate an understanding of how the brain works into clinical treatments for disorders of the brain and nervous system.